MAHATMA GANDHI INSTITUTE OF MEDICAL SCIENCES, WARDHA


About the Bioinformatics Centre
 

Bioinformatics Centre at JB Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences was established in March 1999 with support from Department of Biotechnology, as part of National Bioinformatics Network. The Centre has thrust on Medical / Health Informatics since inception and is actively involved in infectious disease diagnostic research and training. In addition to providing academic bibliography service and in-house Training programme for staff involved in Hospital Information service, the Centre organizes yearly National level Workshop / Seminar / Symposium. So far 16 such events have been organized which were well received and appreciated. Further, this Centre also publishes SEVAMED a Quarterly Update on Infectious Disease Research and Traditional Medicine enters 15th year of its publication and has been well received by the medical teachers and scientists throughout India. In addition to giving selected references and abstracts in hard copy ‘SEVAMED’ is now available online with complete bibliography and link to abstracts for easy retrieval with interactive web pages, beneficial to the researchers, medical practitioners and teachers. For more information, visit http://www.bicjbtdrc-mgims.in/

Area of Specialization: The Bioinformatics Centre has thrust on Medical / Health Informatics

 
Objectives
(Besides, continuing with the ongoing assignments, we wish to take up the new tasks also)
  • Exploring Genome/Proteome analysis of M. tuberculosis & HPV strains and databases development
  • Quarterly updating SEVAMED publication, a quarterly bibliography journal with thrust on infectious diseases & lifestyle health problems
  • Developing & updating web portal on advances in research and health information on emerging infectious diseases and lifestyle health problems
  • Promoting education and human resource development in Bioinformatics
  • Establishing a moving academic platform for curriculum-based training & research in Bioinformatics & Biotechnology
  • Six monthly Online Health Informatics Certification Course
  • Organizing annual National Level Workshops on Biomedical Informatics and Applied Tools & Techniques
 
Achievements at a glance
 
Online Certificate Course on Health Informatics (OHIC)
OHIC, six months certification course is being conducted at Bioinformatics Centre, MGIMS, Sevagram since July 2010 which provides online training to Healthcare personnel and interested graduates in Science, Business Administration & Information Technology and 33 students from UK, Uganda, Mauritius, Ethiopia, Saudi Arabia and from different states of India have registered so far.
 
SEVAMED….goes online with complete bibliography and with link to abstracts
SEVAMED, a quarterly bibliography journal with thrust on infectious diseases & lifestyle health problems has entered 15th year of its publication. This has been well received by the scientists & medical teachers in medical colleges. Bioinformatics centre has launched SEVAMED online as e-journal with complete bibliography and with link to abstracts for easy retrieval with interactive web pages.
 
Web Portals Developed
Centre has launched MGIMS-JBTDRC Arogya Web Portal which presents progress being made in Holistic Healthcare and Research in Lifestyle diseases by Indian Institutions for better awareness, interaction and advancement in holistic therapy and research (http://bicjbtdrc-mgims.in/arogya-webportal/). This web portal basically provides healthcare information at reputed Holistic Healthcare and Research Centers in India on one platform for benefit of medical practitioners and general public.
 
MGIMS-JBTDRC Health Update
MGIMS-JBTDRC Health Update developed and quarterly updates are provided on emerging infectious diseases and lifestyle health problems.
 
Database Developed
Centre has developed customized Database Software for patients’ information and further databases have been developed on Mycobacterial proteases (Mycoprotease-DB, http://www.bicjbtdrc-mgims.in/MycoProtease-DB/), Mycobacterium tuberculosis Proteome comparison (MTB-PCDB, http://www.bicjbtdrc-mgims.in/MTB-PCDB/) and Human Papillomavirus Proteome (hpvPDB, http://www.bicjbtdrc-mgims.in/hpvPDB/).
 
Workshops / Training Program organized
  • National level workshops in Biomedical Informatics and training courses in Infectious Diseases are organized every year. So far 16 such events have been organized which were well received and appreciated.
  • Two sessions on curriculum-based training & research in Bioinformatics, each for 6 days were conducted in April and September, 2013 which was well appreciated. Institutes running Bioinformatics and Biotechnology courses have also requested to conduct such training program in their Institute.
Bioinformatics traineeship and studentship
So far, 13 PG students have completed their projects under Bioinformatics traineeship and studentship programme.
 
Current areas of research
 
  • Genome / Proteome analysis of M. tuberculosis & HPV strains and databases development (Mycoprotease-DB, MTB-PCDB and hpvPDB)
  • Novel inhibitors against HPV through virtual screening
  • TB proteome mutation analysis in different clinical strains to understand drug resistance tuberculosis
  • Exploring the effect of Isoniazid and Orlistat inhibitors on Mtb ES-31 serine protease and other enzymes of interest in TB by computational approach
 


About the Institution
 

Bioinformatics Centre at JB Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences was established in March 1999 with support from Department of Biotechnology, as part of National Bioinformatics Network. The Centre has thrust on Medical / Health Informatics since inception and is actively involved in infectious disease diagnostic research and training. In addition to providing academic bibliography service and in-house Training programme for staff involved in Hospital Information service, the Centre organizes yearly National level Workshop / Seminar / Symposium. So far 16 such events have been organized which were well received and appreciated. Further, this Centre also publishes SEVAMED a Quarterly Update on Infectious Disease Research and Traditional Medicine enters 15th year of its publication and has been well received by the medical teachers and scientists throughout India. In addition to giving selected references and abstracts in hard copy ‘SEVAMED’ is now available online with complete bibliography and link to abstracts for easy retrieval with interactive web pages, beneficial to the researchers, medical practitioners and teachers. For more information, visit http://www.bicjbtdrc-mgims.in/
 
Databases / applications developed
 
The following are the Databases and Software for retrieval of information, comparison and development of evidence based medicine for diagnosis, management & research.
 
MTB - PCDB: Mycobacterium tuberculosis Proteome Comparison Database
MTB-PCDB is an online database with an integrated access to proteome sequence comparison data on five strains of Mycobacterium tuberculosis (H37Rv, H37Ra, CDC 1551, F11 and KZN 1435) sequenced completely so far. Currently hosts 40252 protein sequence comparison data. Proteome comparison data may be beneficial in discovery & development of TB drugs, vaccines and biomarkers.
 
MycoProtease-DB a database of M.tb and NTM proteases
MycoProtease-DB contains protease information of Mycobacterium tuberculosis (MTB) complex and Nontuberculous Mycobacteria (NTM) at gene, protein and structural level whose complete genome sequence is available. Currently hosts 1324 proteases, which include 906 proteases from MTB complex with 237 distinct proteases & 418 from NTM with 404 distinct proteases.
 
HPV-PDB (Human papillomavirus Proteome Database)
The Human papilloma Virus Proteome Database (HPV-PDB) developed at this centre, domiciles proteomic and genomic information on 150 HPV strains sequenced so far. Easy expandability & retrieval of the strain specific data at one place, facility for sequence analysis & exploration potential of predicted structures, easy access to curate and annotate data through various search options etc are few of its important features. Data may be helpful in exploring for designing the drugs and vaccines against several such strains of HPV.
 
Inter Institutionnel collaboration
Exploring collaboration with Dr. Varma Lab at Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Mumbai for structural & functional characterization of HPV strains
 
Infrastructure Facility
 

Bioinformatics Centre at JBTDRC, MGIMS has been established in a carpet area of around 240 sq feet accommodating Information Officer, Technical Assistant, Two data entry operators and a computer operator. Coordinator and Dy coordinator have separate chambers with a few units installed and a scope for further expansion incase required.
Computer & Communication facility:
i. Computer Hardware: (i) Server – 3, (ii) Dell Workstations - 4 (iii) PCs - 19; (iv) Laptop - 3; (v) Printers - 4, (vi) Photocopier, digital copier cum printer - 4 (vii) Cisco Router, (viii) Patton Modem, (ix) Wireless router-2, (x) Switches, (xi) LCD Projector (3), (xii) Scanner, (xiii) Digital Camera, (xiv) Sony Handy cam. (xv) Spiral Binder etc.
Bioinformatics Centre, Immunology & Molecular Biology laboratories are networked through LAN.
ii. Computer Software: Windows NT with service pack 6, Microsoft Windows NT 4.0 Service pack 4, Windows 98, 2000, XP, Office 2007, SQL Svr Standard Edtn 2005 Win 32, Visual Studio Pro 2008, Visio Std 2007, Developer Training Service Pack 3, Microsoft Visual Studio 6.0 Professional Edition with MSDN Library, Adobe Dreamweaver CS3 Win 9.0, Flash Pro CS3 Win 9.0, Adobe Photoshop Extended CS3 10.0, Win Adobe PageMaker 6.5, Wings 2000, Tally 7.2. MATLAB 7, Geneious Pro & freely available online Bioinformatics software for sequence analysis, 3D visualization tools etc. are also being used.
iii. Communication Facility: The Institute has got installed 1 Gbps Internet connectivity and campus is Wi-Fi with high bandwidth.

 
Recent Publications
 

Lingaraja Jena, Supriya Kashikar, Satish Kumar, Bhaskar C. Harinath. Comparative proteomic analysis of Mycobacterium tuberculosis strain H37Rv versus H37Ra. International Journal of Mycobacteriology 2(4): 220 - 226 (2013).

Satish Kumar, Lingaraja Jena, Sangeeta Daf, Kanchan Mohod, Peyush Goyal, Ashok K. Varma. hpvPDB: An Online Proteome Reserve for Human Papillomavirus. Genomics & Informatics 11(4): 1-3 (2013).

Kumar S, Jena L, Mohod K, Daf S, Varma A., In silico inhibitors for human papillomavirus 16 E7 protein, Onl J Bioinform., 14 (3): 302-310, 2013.

Satish Kumar, Lingaraja Jena, Vidya W. Bhomale & Sangeeta Daf. In silico Structural Prediction of E6 and E7 Proteins of Human papillomavirus Strains by Comparative Modeling. International J Bioautomation, 2012;16(2):101-110

Lingaraja Jena, Satish Kumar, Bhaskar Chinnaiah Harinath. MycoProtease-DB: Useful resource for Mycobacterium tuberculosis complex and nontuberculous mycobacterial proteases. Bioinformation 8(24): 1240-1242 (2012)

Lingaraja Jena, Gauri Wankhade, Satish Kumar, Bhaskar Chinnaiah Harinath. MTB-PCDB: Mycobacterium tuberculosis proteome comparison database. Bioinformation 2011;6(3):131-133.
Deshmukh P, Jumde J, Kumar S, Reddy MVR, Harinath BC. FilaDB - Database software for information storage and retrieval on detection and management of filaria patients. Bioinformatics India. Oct-Dec 2005;3(4):36-46.
 
 
 
 
 
Faculty Members
 
Dr. B.C. Harinath, PhD.
Director, JBTDRC
Coordinator, BIC & Arogyadham
  Dr. Satish Kumar, MD
Professor, Biochemistry &
Dy Coordinator, BIC
Mr. Lingaraja Jena
Information Officer, BIC
   
     
Contacts:    
     
Bioinformatics centre
JB Tropical Disease Research Centre
Mahatma Gandhi Institute of Medical Sciences, Sevagram
(Wardha) – 442102, Maharashtra. India
Tele Fax: 07152 – 284038
E-mail: mgims.btisnet@nic.in, info@jbtdrc.org
   
 
Coordinator:
 

Dr. B.C. Harinath, PhD.
Director, JBTDRC

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